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One immediate effect of removing the IR exemplars and cohorts was that PEG's farms packed up and left, leaving BSC farms (from my plugins folder) to develop in their place.
By IR exemplars and cohorts above, do you refer to the IR developers used for the simulation or to the RCI exemplars used by lots? If the latter is true, it isn't any wonder SPAM left town since you removed it alltogether and effectively only have BSC farms, hence the outcome. What I would like to know if SPAM stage 5 farms will actually develop while using the CAM.